The design, construction and three typical applications of a versatile interface for PDP-8 computers, adaptable to PDP-11 systems, are described. The interface is conceived for on-line control and data acquisition in a wide variety of physical and chemical experiments. Design principles and specifications as developed from experience are discussed. A detailed description of such a system is presented, together with three typical on-line applications in the field of ESR, ENDOR and Fourier spectroscopy.