The classical picture of the pre-solar nebula is that of a hot, well-mixed cloud of chemically and isotopically uniform composition. Recent measurements have shown this conception to be erroneous, however. Anomalies have been discovered in the isotopic composition of a number of elements which cannot be explained by processes known to be going on within the solar system at present. Rather, they appear to reflect primordial heterogeneities, testifying to variations in space and/or time of the isotopic composition of these elements within the proto-solar nebula. They contribute to our understanding of processes and of time scales in the early solar system, before and after its formation. Furthermore, they allow one to identify modes of nucleosynthesis and to derive relevant parameters of such production modes.