Defects cause large electronic and mechanical changes in the structure of Chevrel compounds MyMo6S8-zOx, which drastically alter their superconductive properties. Joint treatment of both kinds of changes explains a wide range of experimental data for M = Sn, Pb, Eu and Cu. Constraint theory predicts a solid solubility limit of x = xc = 0.25, in good agreement with experiment. The theory explains quantitatively why dTc/dx is large and negative for M = Sn, Pb and Eu, but positive for M = Cu, and why BaMo6S8, predicted by band theory to be metallic with the highest Tc, is actually semiconductive.