Sharp DNA denaturation due to solvent interaction

Published 1 February 2006 2006 EDP Sciences
, , Citation G. Weber 2006 EPL 73 806 DOI 10.1209/epl/i2005-10466-6

0295-5075/73/5/806

Abstract

Within the framework of the Peyrard-Bishop model for DNA melting, sharp denaturation temperature profiles can currently be obtained only if anharmonic base-pair stacking interactions are considered. We show that, when solvent interactions are included, a sharp denaturation of the DNA double helix is obtained without the need for anharmonic nearest-neighbor interactions. Using the concept of pseudo-Schrödinger equations we discuss the analogy of these transition to quantum-mechanical tunneling, and in particular we show that the sharp transitions are similar to resonant tunneling.

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