The 181Ta(γ, 3n) reaction has been studied by measuring the 9.5 min and 150 min activities of 178Ta. The two 178Ta isomers are produced in the effectively constant ratio A(9.5 min)/A(150min) = 3.0±0.6 by gamma rays of all energies between 24 MeV and 32MeV. The experimental results have been combined with previous determinations of the 181Ta(γ, n) cross section and of the photo-neutron yield to obtain the relative cross sections for the 181Ta(γ, n), (γ, 2n) and (γ, 3n) reactions from their thresholds to 31 MeV. The integrated cross sections for the (γ, n), (γ, 2n) and (γ, 3n) reactions to 31 MeV are (73±3)°0, (24±3)%, and (3.0±1.2)% of the total integrated cross section, (3.3±1.2) MeV barns, for these three photo-neutron reactions.