Paper

The emergence of nanopores in next-generation sequencing

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Published 2 February 2015 © 2015 IOP Publishing Ltd
, , DNA sequencing Citation L J Steinbock and A Radenovic 2015 Nanotechnology 26 074003 DOI 10.1088/0957-4484/26/7/074003

0957-4484/26/7/074003

Abstract

Next-generation sequencing methods based on nanopore technology have recently gained considerable attention, mainly because they promise affordable and fast genome sequencing by providing long read lengths (5 kbp) and do not require additional DNA amplification or enzymatic incorporation of modified nucleotides. This permits health care providers and research facilities to decode a genome within hours for less than $1000. This review summarizes past, present, and future DNA sequencing techniques, which are realized by nanopore approaches such as those pursued by Oxford Nanopore Technologies.

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10.1088/0957-4484/26/7/074003