We study e+e− pair production in proton-proton and in nucleus-nucleus collisions from SIS to LHC energies within the parton-hadron-string dynamics (PHSD) approach which incorporates explicit partonic degrees-of-freedom in terms of strongly interacting quasiparticles (quarks and gluons) in line with an equation-of-state from lattice QCD as well as the dynamical hadronization and hadronic collision dynamics in the final reaction phase. We find a visible in-medium effect in the low mass dilepton sector from dynamical vector-meson spectral functions from SIS to SPS energies whereas at RHIC and LHC energies such medium effects become more moderate. In the intermediate mass regime from 1.1 to 3 GeV pronounced traces of the partonic degrees of freedom are found at SPS and RHIC energies which superseed the hadronic (multi-meson) channels as well as the correlated and uncorrelated semi-leptonic D-meson decays. The dilepton production from the strongly interacting quark gluon plasma (sQGP) becomes already visible at top SPS energies and more pronounced at RHIC and LHC energies.